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NIM811, a Mitochondrial Permeability Transition Inhibitor, Attenuates Cholestatic Liver Injury But Not Fibrosis in Mice
Cholestasis causes hepatocyte death, possibly due to mitochondrial injury. This study investigated whether NIM811, an inhibitor of the mitochondrial permeability transition (MPT), attenuates cholestatic liver injury in vivo. Cholestasis was induced in mice by bile duct ligation (BDL). NIM811 was gav...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2582973/ https://ncbi.nlm.nih.gov/pubmed/18801946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.143578 |
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