Inhibition of Sphingosine Kinase-2 Suppresses Inflammation and Attenuates Graft Injury after Liver Transplantation in Rats

Inflammation mediates/promotes graft injury after liver transplantation (LT). This study investigated the roles of sphingosine kinase-2 (SK2) in inflammation after LT. Liver grafts were stored in UW solution with and without ABC294640 (100 µM), a selective inhibitor of SK2, before implantation. Hepa...

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Autori principali: Liu, Qinlong, Rehman, Hasibur, Shi, Yanjun, Krishnasamy, Yasodha, Lemasters, John J., Smith, Charles D., Zhong, Zhi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405047/
https://ncbi.nlm.nih.gov/pubmed/22848628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041834
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