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Suppression of Ulcerative Colitis in Mice by Orally-Available Inhibitors of Sphingosine Kinase
A critical step in the mechanism of action of inflammatory cytokines is the stimulation of sphingolipid metabolism, including activation of sphingosine kinase (SK) which produces the mitogenic and pro-inflammatory lipid sphingosine 1-phosphate (S1P). We have developed orally-bioavailable compounds t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2660406/ https://ncbi.nlm.nih.gov/pubmed/18058233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10620-007-0133-6 |
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