In Vitro and In Vivo Antitumor and Anti-Inflammatory Capabilities of the Novel GSK3 and CDK9 Inhibitor ABC1183

Glycogen synthase kinase-3s (GSK3α and GSK3β) are constitutively active protein kinases that target over 100 substrates, incorporate into numerous protein complexes, and regulate such vital cellular functions as proliferation, apoptosis, and inflammation. Cyclin-dependent kinase 9 (CDK9) regulates R...

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Опубликовано в: :J Pharmacol Exp Ther
Главные авторы: Schrecengost, Randy S., Green, Cecelia L., Zhuang, Yan, Keller, Staci N., Smith, Ryan A., Maines, Lynn W., Smith, Charles D.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2018
Предметы:
Cellular and Molecular
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830635/
https://ncbi.nlm.nih.gov/pubmed/29434052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.245738
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