GSK 3 inhibition drives maturation of NK cells and enhances their antitumor activity

Maturation of human natural killer cells (NK cells) as defined by accumulation of cell surface expression of CD57 is associated with increased cytotoxic character and TNF and IFN-γ production upon target cell recognition. Notably, multiple studies point to a unique role for CD57(+) NK cells in cance...

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Vydáno v:Cancer Res
Hlavní autoři: Cichocki, Frank, Valamehr, Bahram, Bjordahl, Ryan, Zhang, Bin, Rezner, Betsy, Rogers, Paul, Gaidarova, Svetlana, Moreno, Stacey, Tuininga, Katie, Dougherty, Philip, McCullar, Valarie, Howard, Peter, Sarhan, Dhifaf, Taras, Emily, Schlums, Heinrich, Abbot, Stewart, Shoemaker, Daniel, Bryceson, Yenan T., Blazar, Bruce R., Wolchko, Scott, Cooley, Sarah, Miller, Jeffrey S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645243/
https://ncbi.nlm.nih.gov/pubmed/28790065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0799
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