Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

Impaired estrogen receptor α(ERα) action promotes obesity and metabolic dysfunction in humans and mice; however, the mechanisms underlying these phenotypes remain unknown. Considering that skeletal muscle is a primary tissue responsible for glucose disposal and oxidative metabolism, we established t...

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Pubblicato in:Sci Transl Med
Autori principali: Ribas, Vicent, Drew, Brian G., Zhou, Zhenqi, Phun, Jennifer, Kalajian, Nareg Y., Soleymani, Teo, Daraei, Pedram, Widjaja, Kevin, Wanagat, Jonathan, de Aguiar Vallim, Thomas Q., Fluitt, Amy H., Bensinger, Steven, Le, Thuc, Radu, Caius, Whitelegge, Julian P., Beaven, Simon W., Tontonoz, Peter, Lusis, Aldons J., Parks, Brian W., Vergnes, Laurent, Reue, Karen, Singh, Harpreet, Bopassa, Jean C., Toro, Ligia, Stefani, Enrico, Watt, Matthew J., Schenk, Simon, Akerstrom, Thorbjorn, Kelly, Meghan, Pedersen, Bente K., Hewitt, Sylvia C., Korach, Kenneth S., Hevener, Andrea L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934679/
https://ncbi.nlm.nih.gov/pubmed/27075628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad3815
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