Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

Impaired estrogen receptor α(ERα) action promotes obesity and metabolic dysfunction in humans and mice; however, the mechanisms underlying these phenotypes remain unknown. Considering that skeletal muscle is a primary tissue responsible for glucose disposal and oxidative metabolism, we established t...

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Udgivet i:Sci Transl Med
Main Authors: Ribas, Vicent, Drew, Brian G., Zhou, Zhenqi, Phun, Jennifer, Kalajian, Nareg Y., Soleymani, Teo, Daraei, Pedram, Widjaja, Kevin, Wanagat, Jonathan, de Aguiar Vallim, Thomas Q., Fluitt, Amy H., Bensinger, Steven, Le, Thuc, Radu, Caius, Whitelegge, Julian P., Beaven, Simon W., Tontonoz, Peter, Lusis, Aldons J., Parks, Brian W., Vergnes, Laurent, Reue, Karen, Singh, Harpreet, Bopassa, Jean C., Toro, Ligia, Stefani, Enrico, Watt, Matthew J., Schenk, Simon, Akerstrom, Thorbjorn, Kelly, Meghan, Pedersen, Bente K., Hewitt, Sylvia C., Korach, Kenneth S., Hevener, Andrea L.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934679/
https://ncbi.nlm.nih.gov/pubmed/27075628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad3815
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