Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress

Estrogen receptor α (ERα) action plays an important role in pancreatic β-cell function and survival; thus, it is considered a potential therapeutic target for the treatment of type 2 diabetes in women. However, the mechanisms underlying the protective effects of ERα remain unclear. Because ERα regul...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhou, Zhenqi, Ribas, Vicent, Rajbhandari, Prashant, Drew, Brian G., Moore, Timothy M., Fluitt, Amy H., Reddish, Britany R., Whitney, Kate A., Georgia, Senta, Vergnes, Laurent, Reue, Karen, Liesa, Marc, Shirihai, Orian, van der Bliek, Alexander M., Chi, Nai-Wen, Mahata, Sushil K., Tiano, Joseph P., Hewitt, Sylvia C., Tontonoz, Peter, Korach, Kenneth S., Mauvais-Jarvis, Franck, Hevener, Andrea L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880140/
https://ncbi.nlm.nih.gov/pubmed/29378845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.805069
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