Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress

Estrogen receptor α (ERα) action plays an important role in pancreatic β-cell function and survival; thus, it is considered a potential therapeutic target for the treatment of type 2 diabetes in women. However, the mechanisms underlying the protective effects of ERα remain unclear. Because ERα regul...

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Опубликовано в: :J Biol Chem
Главные авторы: Zhou, Zhenqi, Ribas, Vicent, Rajbhandari, Prashant, Drew, Brian G., Moore, Timothy M., Fluitt, Amy H., Reddish, Britany R., Whitney, Kate A., Georgia, Senta, Vergnes, Laurent, Reue, Karen, Liesa, Marc, Shirihai, Orian, van der Bliek, Alexander M., Chi, Nai-Wen, Mahata, Sushil K., Tiano, Joseph P., Hewitt, Sylvia C., Tontonoz, Peter, Korach, Kenneth S., Mauvais-Jarvis, Franck, Hevener, Andrea L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2018
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880140/
https://ncbi.nlm.nih.gov/pubmed/29378845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.805069
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