Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress

Estrogen receptor α (ERα) action plays an important role in pancreatic β-cell function and survival; thus, it is considered a potential therapeutic target for the treatment of type 2 diabetes in women. However, the mechanisms underlying the protective effects of ERα remain unclear. Because ERα regul...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Zhou, Zhenqi, Ribas, Vicent, Rajbhandari, Prashant, Drew, Brian G., Moore, Timothy M., Fluitt, Amy H., Reddish, Britany R., Whitney, Kate A., Georgia, Senta, Vergnes, Laurent, Reue, Karen, Liesa, Marc, Shirihai, Orian, van der Bliek, Alexander M., Chi, Nai-Wen, Mahata, Sushil K., Tiano, Joseph P., Hewitt, Sylvia C., Tontonoz, Peter, Korach, Kenneth S., Mauvais-Jarvis, Franck, Hevener, Andrea L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2018
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880140/
https://ncbi.nlm.nih.gov/pubmed/29378845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.805069
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