Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling

Obesity is heightened during aging, and although the estrogen receptor α (ERα) has been implicated in the prevention of obesity, its molecular actions in adipocytes remain inadequately understood. Here, we show that adipose tissue ESR1/Esr1 expression inversely associated with adiposity and positive...

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Publicado en:Sci Transl Med
Main Authors: Zhou, Zhenqi, Moore, Timothy M., Drew, Brian G., Ribas, Vicent, Wanagat, Jonathan, Civelek, Mete, Segawa, Mayuko, Wolf, Dane M., Norheim, Frode, Seldin, Marcus M., Strumwasser, Alexander R., Whitney, Kate A., Lester, Ellen, Reddish, Britany R., Vergnes, Laurent, Reue, Karen, Rajbhandari, Prashant, Tontonoz, Peter, Lee, Jason, Mahata, Sushil K., Hewitt, Sylvia C., Shirihai, Orian, Gastonbury, Craig, Small, Kerrin S., Laakso, Markku, Jensen, Jorgen, Lee, Sindre, Drevon, Christian A., Korach, Kenneth S., Lusis, Aldons J., Hevener, Andrea L.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212422/
https://ncbi.nlm.nih.gov/pubmed/32759275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax8096
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