Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling

Obesity is heightened during aging, and although the estrogen receptor α (ERα) has been implicated in the prevention of obesity, its molecular actions in adipocytes remain inadequately understood. Here, we show that adipose tissue ESR1/Esr1 expression inversely associated with adiposity and positive...

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Pubblicato in:Sci Transl Med
Autori principali: Zhou, Zhenqi, Moore, Timothy M., Drew, Brian G., Ribas, Vicent, Wanagat, Jonathan, Civelek, Mete, Segawa, Mayuko, Wolf, Dane M., Norheim, Frode, Seldin, Marcus M., Strumwasser, Alexander R., Whitney, Kate A., Lester, Ellen, Reddish, Britany R., Vergnes, Laurent, Reue, Karen, Rajbhandari, Prashant, Tontonoz, Peter, Lee, Jason, Mahata, Sushil K., Hewitt, Sylvia C., Shirihai, Orian, Gastonbury, Craig, Small, Kerrin S., Laakso, Markku, Jensen, Jorgen, Lee, Sindre, Drevon, Christian A., Korach, Kenneth S., Lusis, Aldons J., Hevener, Andrea L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212422/
https://ncbi.nlm.nih.gov/pubmed/32759275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax8096
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