PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

Prostate cancer has the second highest incidence among cancers in men worldwide and is the second leading cause of cancer deaths of men in the United States. Although androgen deprivation can initially lead to remission, the disease often progresses to castration-resistant prostate cancer (CRPC), wh...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Raina, Kanak, Lu, Jing, Qian, Yimin, Altieri, Martha, Gordon, Deborah, Rossi, Ann Marie K., Wang, Jing, Chen, Xin, Dong, Hanqing, Siu, Kam, Winkler, James D., Crew, Andrew P., Crews, Craig M., Coleman, Kevin G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932933/
https://ncbi.nlm.nih.gov/pubmed/27274052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521738113
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