PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

Prostate cancer has the second highest incidence among cancers in men worldwide and is the second leading cause of cancer deaths of men in the United States. Although androgen deprivation can initially lead to remission, the disease often progresses to castration-resistant prostate cancer (CRPC), wh...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Raina, Kanak, Lu, Jing, Qian, Yimin, Altieri, Martha, Gordon, Deborah, Rossi, Ann Marie K., Wang, Jing, Chen, Xin, Dong, Hanqing, Siu, Kam, Winkler, James D., Crew, Andrew P., Crews, Craig M., Coleman, Kevin G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932933/
https://ncbi.nlm.nih.gov/pubmed/27274052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521738113
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