Global identification of hnRNP A1 binding sites for SSO-based splicing modulation

BACKGROUND: Many pathogenic genetic variants have been shown to disrupt mRNA splicing. Besides splice mutations in the well-conserved splice sites, mutations in splicing regulatory elements (SREs) may deregulate splicing and cause disease. A promising therapeutic approach is to compensate for this d...

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Vydáno v:BMC Biol
Hlavní autoři: Bruun, Gitte H., Doktor, Thomas K., Borch-Jensen, Jonas, Masuda, Akio, Krainer, Adrian R., Ohno, Kinji, Andresen, Brage S.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932749/
https://ncbi.nlm.nih.gov/pubmed/27380775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-016-0279-9
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