Global identification of hnRNP A1 binding sites for SSO-based splicing modulation

BACKGROUND: Many pathogenic genetic variants have been shown to disrupt mRNA splicing. Besides splice mutations in the well-conserved splice sites, mutations in splicing regulatory elements (SREs) may deregulate splicing and cause disease. A promising therapeutic approach is to compensate for this d...

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Enregistré dans:
Détails bibliographiques
Publié dans:BMC Biol
Auteurs principaux: Bruun, Gitte H., Doktor, Thomas K., Borch-Jensen, Jonas, Masuda, Akio, Krainer, Adrian R., Ohno, Kinji, Andresen, Brage S.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932749/
https://ncbi.nlm.nih.gov/pubmed/27380775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-016-0279-9
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