Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development

Cytochrome P450s are oxidative metabolic enzymes that play critical roles in the biotransformation of endogenous compounds and xenobiotics. The expression and activity of P450 enzymes varies considerably throughout human development; the deficit in our understanding of these dynamics limits our abil...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Sadler, Natalie C., Nandhikonda, Premchendar, Webb-Robertson, Bobbie-Jo, Ansong, Charles, Anderson, Lindsey N., Smith, Jordan N., Corley, Richard A., Wright, Aaron T.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Special Section on Pediatric Drug Disposition and Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931891/
https://ncbi.nlm.nih.gov/pubmed/27084891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.068593
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