Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant

For infants and very young children with brain tumors, chemotherapy after surgical resection is the main treatment due to neurologic and neuroendocrine adverse effects from whole brain irradiation. Topotecan, an anticancer drug with antitumor activity against pediatric brain tumors, can be given int...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Roberts, Jessica K., Birg, Anna V., Lin, Tong, Daryani, Vinay M., Panetta, John C., Broniscer, Alberto, Robinson, Giles W., Gajjar, Amar J., Stewart, Clinton F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Special Section on Pediatric Drug Disposition and Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931885/
https://ncbi.nlm.nih.gov/pubmed/27052877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.068676
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