Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant

For infants and very young children with brain tumors, chemotherapy after surgical resection is the main treatment due to neurologic and neuroendocrine adverse effects from whole brain irradiation. Topotecan, an anticancer drug with antitumor activity against pediatric brain tumors, can be given int...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Drug Metab Dispos
Κύριοι συγγραφείς: Roberts, Jessica K., Birg, Anna V., Lin, Tong, Daryani, Vinay M., Panetta, John C., Broniscer, Alberto, Robinson, Giles W., Gajjar, Amar J., Stewart, Clinton F.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The American Society for Pharmacology and Experimental Therapeutics 2016
Θέματα:
Special Section on Pediatric Drug Disposition and Pharmacokinetics
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931885/
https://ncbi.nlm.nih.gov/pubmed/27052877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.068676
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