Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant

For infants and very young children with brain tumors, chemotherapy after surgical resection is the main treatment due to neurologic and neuroendocrine adverse effects from whole brain irradiation. Topotecan, an anticancer drug with antitumor activity against pediatric brain tumors, can be given int...

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Publicado en:Drug Metab Dispos
Autores principales: Roberts, Jessica K., Birg, Anna V., Lin, Tong, Daryani, Vinay M., Panetta, John C., Broniscer, Alberto, Robinson, Giles W., Gajjar, Amar J., Stewart, Clinton F.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
Materias:
Special Section on Pediatric Drug Disposition and Pharmacokinetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931885/
https://ncbi.nlm.nih.gov/pubmed/27052877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.068676
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