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Determining success rates of the current pharmacokinetically-guided dosing approach of topotecan in pediatric oncology patients
BACKGROUND: Topotecan is a chemotherapeutic agent that is active against many pediatric tumors. Although its effect is related to systemic exposure, the interpatient variability in systemic clearance makes it challenging to achieve desired topotecan targets. This study aims to evaluate the success o...
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| Publié dans: | Pediatr Blood Cancer |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6386591/ https://ncbi.nlm.nih.gov/pubmed/30548417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.27578 |
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