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Using plasma topotecan pharmacokinetics to estimate topotecan exposure in cerebrospinal fluid of children with medulloblastoma
The purpose of this study was to estimate ventricular cerebrospinal fluid (vCSF) topotecan lactone (TPT) exposures in pediatric medulloblastoma patients from plasma concentration–time data by using a pharmaco‐kinetic (PK) model. We studied children with high‐risk medulloblastoma who received pharmac...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Duke University Press
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1871944/ https://ncbi.nlm.nih.gov/pubmed/16461424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2005-004 |
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