Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors

PURPOSE: This study was designed to ascertain the dose-limiting toxicities (DLT) and maximally tolerated doses of the combination of fixed-dose tamoxifen and carboplatin, with escalating doses of topotecan, and to determine the pharmacokinetics of topotecan in the plasma and cerebrospinal fluid. MET...

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Detalhes bibliográficos
Main Authors: Morgan, Robert J., Synold, Timothy, Mamelak, Adam, Lim, Dean, Al-Kadhimi, Zaid, Twardowski, Przemyslaw, Leong, Lucille, Chow, Warren, Margolin, Kim, Shibata, Stephen, Somlo, George, Yen, Yun, Frankel, Paul, Doroshow, James H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265324/
https://ncbi.nlm.nih.gov/pubmed/20107803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1242-z
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