Pharmacokinetic basis for dosing high‐dose methotrexate in infants and young children with malignant brain tumours

AIMS: No population pharmacokinetic studies of high‐dose methotrexate (HDMTX) have been conducted in infants with brain tumours, which are a vulnerable population. The aim of this study was to evaluate HDMTX disposition in these children to provide a rational basis for MTX dosing. METHODS: Patients...

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Bibliografiska uppgifter
I publikationen:Br J Clin Pharmacol
Huvudupphovsmän: Panetta, John C., Roberts, Jessica K., Huang, Jie, Lin, Tong, Daryani, Vinay M., Harstead, K. Elaine, Patel, Yogesh T., Onar‐Thomas, Arzu, Campagne, Olivia, Ward, Deborah A., Broniscer, Alberto, Robinson, Giles, Gajjar, Amar, Stewart, Clinton F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2020
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015755/
https://ncbi.nlm.nih.gov/pubmed/31657864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14160
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