Pharmacokinetic basis for dosing high‐dose methotrexate in infants and young children with malignant brain tumours

AIMS: No population pharmacokinetic studies of high‐dose methotrexate (HDMTX) have been conducted in infants with brain tumours, which are a vulnerable population. The aim of this study was to evaluate HDMTX disposition in these children to provide a rational basis for MTX dosing. METHODS: Patients...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Panetta, John C., Roberts, Jessica K., Huang, Jie, Lin, Tong, Daryani, Vinay M., Harstead, K. Elaine, Patel, Yogesh T., Onar‐Thomas, Arzu, Campagne, Olivia, Ward, Deborah A., Broniscer, Alberto, Robinson, Giles, Gajjar, Amar, Stewart, Clinton F.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015755/
https://ncbi.nlm.nih.gov/pubmed/31657864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14160
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