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2-Phenethyl isothiocyanate, glutathione S-transferase M1 and T1 polymorphisms, and detoxification of volatile organic carcinogens and toxicants in tobacco smoke

Cigarette smoke contains relatively large quantities of volatile organic toxicants or carcinogens such as benzene, acrolein and crotonaldehyde. Among their detoxification products are mercapturic acids formed from glutathione conjugation, catalyzed in part by glutathione S-transferases (GST). A rand...

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Detalhes bibliográficos
Publicado no:Cancer Prev Res (Phila)
Main Authors: Yuan, Jian-Min, Murphy, Sharon E., Stepanov, Irina, Wang, Renwei, Carmella, Steven G., Nelson, Heather H., Hatsukami, Dorothy, Hecht, Stephen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930697/
https://ncbi.nlm.nih.gov/pubmed/27099270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-16-0032
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