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Oxidative DNA damage stalls the human mitochondrial replisome

Oxidative stress is capable of causing damage to various cellular constituents, including DNA. There is however limited knowledge on how oxidative stress influences mitochondrial DNA and its replication. Here, we have used purified mtDNA replication proteins, i.e. DNA polymerase γ holoenzyme, the mi...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Stojkovič, Gorazd, Makarova, Alena V., Wanrooij, Paulina H., Forslund, Josefin, Burgers, Peter M., Wanrooij, Sjoerd
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929447/
https://ncbi.nlm.nih.gov/pubmed/27364318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28942
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