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Oxidative DNA damage stalls the human mitochondrial replisome

Oxidative stress is capable of causing damage to various cellular constituents, including DNA. There is however limited knowledge on how oxidative stress influences mitochondrial DNA and its replication. Here, we have used purified mtDNA replication proteins, i.e. DNA polymerase γ holoenzyme, the mi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Stojkovič, Gorazd, Makarova, Alena V., Wanrooij, Paulina H., Forslund, Josefin, Burgers, Peter M., Wanrooij, Sjoerd
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929447/
https://ncbi.nlm.nih.gov/pubmed/27364318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28942
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