Optimization of the expression, purification and polymerase activity reaction conditions of recombinant human PrimPol

Human PrimPol is a DNA primase/polymerase involved in DNA damage tolerance and prevents nuclear genome instability. PrimPol is also localized to the mitochondria, but its precise function in mitochondrial DNA maintenance has remained elusive. PrimPol works both as a translesion (TLS) polymerase and...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Boldinova, Elizaveta O., Stojkovič, Gorazd, Khairullin, Rafil, Wanrooij, Sjoerd, Makarova, Alena V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5597260/
https://ncbi.nlm.nih.gov/pubmed/28902865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184489
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