A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol

Replication forks often stall at damaged DNA. To overcome these obstructions and complete the DNA duplication in a timely fashion, replication can be restarted downstream of the DNA lesion. In mammalian cells, this repriming of replication can be achieved through the activities of primase and polyme...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Kasho, Kazutoshi, Stojkovič, Gorazd, Velázquez-Ruiz, Cristina, Martínez-Jiménez, Maria Isabel, Doimo, Mara, Laurent, Timothée, Berner, Andreas, Pérez-Rivera, Aldo E, Jenninger, Louise, Blanco, Luis, Wanrooij, Sjoerd
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913696/
https://ncbi.nlm.nih.gov/pubmed/33533925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab049
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