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Human Polymerase δ-Interacting Protein 2 (PolDIP2) Inhibits the Formation of Human Tau Oligomers and Fibrils

A central characteristic of Alzheimer’s disease (AD) and other tauopathies is the accumulation of aggregated and misfolded Tau deposits in the brain. Tau-targeting therapies for AD have been unsuccessful in patients to date. Here we show that human polymerase δ-interacting protein 2 (PolDIP2) intera...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Kasho, Kazutoshi, Krasauskas, Lukas, Smirnovas, Vytautas, Stojkovič, Gorazd, Morozova-Roche, Ludmilla A., Wanrooij, Sjoerd
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8199196/
https://ncbi.nlm.nih.gov/pubmed/34071254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22115768
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