Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired

Incorporation of ribonucleotides into DNA during genome replication is a significant source of genomic instability. The frequency of ribonucleotides in DNA is determined by deoxyribonucleoside triphosphate/ribonucleoside triphosphate (dNTP/rNTP) ratios, by the ability of DNA polymerases to discrimin...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Wanrooij, Paulina H., Engqvist, Martin K. M., Forslund, Josefin M. E., Navarrete, Clara, Nilsson, Anna Karin, Sedman, Juhan, Wanrooij, Sjoerd, Clausen, Anders R., Chabes, Andrei
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703314/
https://ncbi.nlm.nih.gov/pubmed/29109257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713085114
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