Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial DNA

Previous work has demonstrated the presence of ribonucleotides in human mitochondrial DNA (mtDNA) and in the present study we use a genome-wide approach to precisely map the location of these. We find that ribonucleotides are distributed evenly between the heavy- and light-strand of mtDNA. The relat...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Berglund, Anna-Karin, Navarrete, Clara, Engqvist, Martin K. M., Hoberg, Emily, Szilagyi, Zsolt, Taylor, Robert W., Gustafsson, Claes M., Falkenberg, Maria, Clausen, Anders R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336301/
https://ncbi.nlm.nih.gov/pubmed/28207748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006628
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