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The presence of rNTPs decreases the speed of mitochondrial DNA replication
Ribonucleotides (rNMPs) are frequently incorporated during replication or repair by DNA polymerases and failure to remove them leads to instability of nuclear DNA (nDNA). Conversely, rNMPs appear to be relatively well-tolerated in mitochondrial DNA (mtDNA), although the mechanisms behind the toleran...
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| Pubblicato in: | PLoS Genet |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5895052/ https://ncbi.nlm.nih.gov/pubmed/29601571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007315 |
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