Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist

Ca(2+)-sensing receptors (CaSRs) modulate calcium and magnesium homeostasis and many (patho)physiological processes by responding to extracellular stimuli, including divalent cations and amino acids. We report the first crystal structure of the extracellular domain (ECD) of human CaSR bound with Mg(...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Zhang, Chen, Zhang, Tuo, Zou, Juan, Miller, Cassandra Lynn, Gorkhali, Rakshya, Yang, Jeong-Yeh, Schilmiller, Anthony, Wang, Shuo, Huang, Kenneth, Brown, Edward M., Moremen, Kelley W., Hu, Jian, Yang, Jenny J.
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2016
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928972/
https://ncbi.nlm.nih.gov/pubmed/27386547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600241
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