Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist

Ca(2+)-sensing receptors (CaSRs) modulate calcium and magnesium homeostasis and many (patho)physiological processes by responding to extracellular stimuli, including divalent cations and amino acids. We report the first crystal structure of the extracellular domain (ECD) of human CaSR bound with Mg(...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Adv
Prif Awduron: Zhang, Chen, Zhang, Tuo, Zou, Juan, Miller, Cassandra Lynn, Gorkhali, Rakshya, Yang, Jeong-Yeh, Schilmiller, Anthony, Wang, Shuo, Huang, Kenneth, Brown, Edward M., Moremen, Kelley W., Hu, Jian, Yang, Jenny J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Association for the Advancement of Science 2016
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928972/
https://ncbi.nlm.nih.gov/pubmed/27386547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600241
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg