Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist

Ca(2+)-sensing receptors (CaSRs) modulate calcium and magnesium homeostasis and many (patho)physiological processes by responding to extracellular stimuli, including divalent cations and amino acids. We report the first crystal structure of the extracellular domain (ECD) of human CaSR bound with Mg(...

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Bibliografische gegevens
Gepubliceerd in:Sci Adv
Hoofdauteurs: Zhang, Chen, Zhang, Tuo, Zou, Juan, Miller, Cassandra Lynn, Gorkhali, Rakshya, Yang, Jeong-Yeh, Schilmiller, Anthony, Wang, Shuo, Huang, Kenneth, Brown, Edward M., Moremen, Kelley W., Hu, Jian, Yang, Jenny J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Association for the Advancement of Science 2016
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928972/
https://ncbi.nlm.nih.gov/pubmed/27386547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600241
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