Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist

Ca(2+)-sensing receptors (CaSRs) modulate calcium and magnesium homeostasis and many (patho)physiological processes by responding to extracellular stimuli, including divalent cations and amino acids. We report the first crystal structure of the extracellular domain (ECD) of human CaSR bound with Mg(...

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Bibliografski detalji
Izdano u:Sci Adv
Glavni autori: Zhang, Chen, Zhang, Tuo, Zou, Juan, Miller, Cassandra Lynn, Gorkhali, Rakshya, Yang, Jeong-Yeh, Schilmiller, Anthony, Wang, Shuo, Huang, Kenneth, Brown, Edward M., Moremen, Kelley W., Hu, Jian, Yang, Jenny J.
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2016
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928972/
https://ncbi.nlm.nih.gov/pubmed/27386547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600241
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