In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine

BACKGROUND: Genome-wide methylation of cytosine can be modulated in the presence of TET and thymine DNA glycosylase (TDG) enzymes. TET is able to oxidise 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TDG can excise the oxidative produ...

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Vydáno v:Genome Biol
Hlavní autoři: Iurlaro, Mario, McInroy, Gordon R., Burgess, Heather E., Dean, Wendy, Raiber, Eun-Ang, Bachman, Martin, Beraldi, Dario, Balasubramanian, Shankar, Reik, Wolf
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928330/
https://ncbi.nlm.nih.gov/pubmed/27356509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-1001-5
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