5-Formylcytosine can be a stable DNA modification in mammals

5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable isotope labeling in vivo, we show that 5fC c...

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Pubblicato in:Nat Chem Biol
Autori principali: Bachman, Martin, Uribe-Lewis, Santiago, Yang, Xiaoping, Burgess, Heather E, Iurlaro, Mario, Reik, Wolf, Murrell, Adele, Balasubramanian, Shankar
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486442/
https://ncbi.nlm.nih.gov/pubmed/26098680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1848
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