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5-Formylcytosine can be a stable DNA modification in mammals

5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable isotope labeling in vivo, we show that 5fC c...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Bachman, Martin, Uribe-Lewis, Santiago, Yang, Xiaoping, Burgess, Heather E, Iurlaro, Mario, Reik, Wolf, Murrell, Adele, Balasubramanian, Shankar
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486442/
https://ncbi.nlm.nih.gov/pubmed/26098680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1848
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