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5-Formylcytosine can be a stable DNA modification in mammals
5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable isotope labeling in vivo, we show that 5fC c...
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| Veröffentlicht in: | Nat Chem Biol |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5486442/ https://ncbi.nlm.nih.gov/pubmed/26098680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1848 |
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