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5-Hydroxymethylcytosine is a predominantly stable DNA modification
5-Hydroxymethylcytosine (hmC) is an oxidation product of 5-methylcytosine (mC) present in DNA of most mammalian cells. Reduction of hmC levels in DNA is a hallmark of cancers. Elucidating the dynamics of this oxidation reaction and the lifetime of hmC in DNA is fundamental to understanding hmC funct...
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| Publicado no: | Nat Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4382525/ https://ncbi.nlm.nih.gov/pubmed/25411882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2064 |
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