5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer

BACKGROUND: The discovery of cytosine hydroxymethylation (5hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behaviour in colon cancer. 5hmC is globally reduced in proliferating cells such as colon tumours and the gut crypt prog...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Uribe-Lewis, Santiago, Stark, Rory, Carroll, Thomas, Dunning, Mark J, Bachman, Martin, Ito, Yoko, Stojic, Lovorka, Halim, Silvia, Vowler, Sarah L, Lynch, Andy G, Delatte, Benjamin, de Bony, Eric J, Colin, Laurence, Defrance, Matthieu, Krueger, Felix, Silva, Ana-Luisa, ten Hoopen, Rogier, Ibrahim, Ashraf EK, Fuks, François, Murrell, Adele
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380107/
https://ncbi.nlm.nih.gov/pubmed/25853800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0605-5
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