Loss of Tet1 associated 5-hydroxymethylcytosine is concomitant with aberrant promoter hypermethylation in liver cancer

Aberrant hypermethylation of CpG islands (CGI) in human tumors occurs predominantly at repressed genes in the host tissue, but the preceding events driving this phenomenon are poorly understood. In this study, we temporally tracked epigenetic and transcriptomic perturbations which occur in a mouse m...

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Bibliografiska uppgifter
I publikationen:Cancer Res
Huvudupphovsmän: Thomson, John P, Ottaviano, Raffaele, Unterberger, Elif, Lempiäinen, Harri, Muller, Arne, Terranova, Remi, Illingworth, Robert S., Webb, Shaun, Kerr, Alastair R. W., Lyall, Marcus J, Drake, Amanda J, Wolf, C Roland, Moggs, Jonathan G, Schwarz, Michael, Meehan, Richard R
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021200/
https://ncbi.nlm.nih.gov/pubmed/27197233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1910
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