Loss of Tet1 associated 5-hydroxymethylcytosine is concomitant with aberrant promoter hypermethylation in liver cancer

Aberrant hypermethylation of CpG islands (CGI) in human tumors occurs predominantly at repressed genes in the host tissue, but the preceding events driving this phenomenon are poorly understood. In this study, we temporally tracked epigenetic and transcriptomic perturbations which occur in a mouse m...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Thomson, John P, Ottaviano, Raffaele, Unterberger, Elif, Lempiäinen, Harri, Muller, Arne, Terranova, Remi, Illingworth, Robert S., Webb, Shaun, Kerr, Alastair R. W., Lyall, Marcus J, Drake, Amanda J, Wolf, C Roland, Moggs, Jonathan G, Schwarz, Michael, Meehan, Richard R
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021200/
https://ncbi.nlm.nih.gov/pubmed/27197233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1910
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