Loss of Tet1 associated 5-hydroxymethylcytosine is concomitant with aberrant promoter hypermethylation in liver cancer

Aberrant hypermethylation of CpG islands (CGI) in human tumors occurs predominantly at repressed genes in the host tissue, but the preceding events driving this phenomenon are poorly understood. In this study, we temporally tracked epigenetic and transcriptomic perturbations which occur in a mouse m...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Res
Egile Nagusiak: Thomson, John P, Ottaviano, Raffaele, Unterberger, Elif, Lempiäinen, Harri, Muller, Arne, Terranova, Remi, Illingworth, Robert S., Webb, Shaun, Kerr, Alastair R. W., Lyall, Marcus J, Drake, Amanda J, Wolf, C Roland, Moggs, Jonathan G, Schwarz, Michael, Meehan, Richard R
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021200/
https://ncbi.nlm.nih.gov/pubmed/27197233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1910
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