5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer

BACKGROUND: The discovery of cytosine hydroxymethylation (5hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behaviour in colon cancer. 5hmC is globally reduced in proliferating cells such as colon tumours and the gut crypt prog...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Uribe-Lewis, Santiago, Stark, Rory, Carroll, Thomas, Dunning, Mark J, Bachman, Martin, Ito, Yoko, Stojic, Lovorka, Halim, Silvia, Vowler, Sarah L, Lynch, Andy G, Delatte, Benjamin, de Bony, Eric J, Colin, Laurence, Defrance, Matthieu, Krueger, Felix, Silva, Ana-Luisa, ten Hoopen, Rogier, Ibrahim, Ashraf EK, Fuks, François, Murrell, Adele
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380107/
https://ncbi.nlm.nih.gov/pubmed/25853800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0605-5
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