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5-hydroxymethylcytosine: a stable or transient DNA modification?
The DNA base 5-hydroxymethylcytosine (5hmC) is produced by enzymatic oxidation of 5-methylcytosine (5mC) by 5mC oxidases (the Tet proteins). Since 5hmC is recognized poorly by DNA methyltransferases, DNA methylation may be lost at 5hmC sites during DNA replication. In addition, 5hmC can be oxidized...
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| Publicado no: | Genomics |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4252803/ https://ncbi.nlm.nih.gov/pubmed/25181633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygeno.2014.08.015 |
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