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Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme

Sml1 is an intrinsically disordered protein inhibitor of Saccharomyces cerevisiae ribonucleotide reductase (ScRR1), but its inhibition is poorly understood. RR reduces ribonucleoside diphosphates to their deoxy forms, and balances the nucleotide pool. Multiple turnover kinetics show that Sml1 inhibi...

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Библиографические подробности
Опубликовано в: :FEBS Lett
Главные авторы: Misko, Tessianna A., Wijerathna, Sanath R., Radivoyevitch, Tomas, Berdis, Anthony J., Ahmad, Md. Faiz, Harris, Michael E., Dealwis, Chris G.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4925217/
https://ncbi.nlm.nih.gov/pubmed/27155231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12207
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