Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy

Ribonucleotide reductase (RR) is a crucial enzyme in de novo DNA synthesis, where it catalyses the rate determining step of dNTP synthesis. RRs consist of a large subunit called RR1 (α), that contains two allosteric sites and one catalytic site, and a small subunit called RR2 (β), which houses a tyr...

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Main Authors: Wijerathna, Sanath R., Ahmad, Md. Faiz, Xu, Hai, Fairman, James W., Zhang, Andrew, Kaushal, Prem Singh, Wan, Qun, Kiser, Jianying, Dealwis, Chris G.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2011
Assuntos:
Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483043/
https://ncbi.nlm.nih.gov/pubmed/23115527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph4101328
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