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Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy
Ribonucleotide reductase (RR) is a crucial enzyme in de novo DNA synthesis, where it catalyses the rate determining step of dNTP synthesis. RRs consist of a large subunit called RR1 (α), that contains two allosteric sites and one catalytic site, and a small subunit called RR2 (β), which houses a tyr...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3483043/ https://ncbi.nlm.nih.gov/pubmed/23115527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph4101328 |
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