The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: a Conformationally Flexible Pharmacophore

Eukaryotic ribonucleotide reductase (RR) catalyzes nucleoside diphosphate conversion to deoxynucleoside diphosphate. Crucial for rapidly dividing cells, RR is a target for cancer therapy. RR activity requires formation of a complex between subunits R1 and R2 in which the R2 C-terminal peptide binds...

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Main Authors: Xu, Hai, Fairman, James W., Wijerathna, Sanath R., Kreischer, Nathan R., LaMacchia, John, Helmbrecht, Elizabeth, Cooperman, Barry S., Dealwis, Chris
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726620/
https://ncbi.nlm.nih.gov/pubmed/18610997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800350u
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