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Structure-based Design, Synthesis, and Evaluation of 2′-(2-Hydroxyethyl)-2′-Deoxyadenosine and Its 5′-Diphosphate as Novel Ribonucleotide Reductase Inhibitors
Analysis of the recently solved X-ray crystal structures of yeast ribonucleotide reductase I (RnrI) in complex with effectors and substrates led to the discovery of a conserved water molecule located at the active site that interacted with the 2′ hydroxy of the nucleoside ribose. In this study 2′-(2...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3080699/ https://ncbi.nlm.nih.gov/pubmed/19681093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200900236 |
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