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Structure-based Design, Synthesis, and Evaluation of 2′-(2-Hydroxyethyl)-2′-Deoxyadenosine and Its 5′-Diphosphate as Novel Ribonucleotide Reductase Inhibitors

Analysis of the recently solved X-ray crystal structures of yeast ribonucleotide reductase I (RnrI) in complex with effectors and substrates led to the discovery of a conserved water molecule located at the active site that interacted with the 2′ hydroxy of the nucleoside ribose. In this study 2′-(2...

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Autors principals: Sun, Dianqing, Xu, Hai, Wijerathna, Sanath, R., Dealwis, Chris, Lee, Richard E.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080699/
https://ncbi.nlm.nih.gov/pubmed/19681093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200900236
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